Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Hayes, M. Geoffrey; Urbanek, Margrit; Ehrmann, David A.; Armstrong, Loren L.; Lee, Ji Young; Sisk, Ryan; Karaderi, Tugce; Barber, Thomas M.; McCarthy, Mark I.; Franks, Stephen; Lindgren, Cecilia M.; Welt, Corrine K.; Diamanti‐Kandarakis, Evanthia; Panidis, Dimitrios; Goodarzi, Mark O.; Azziz, Ricardo; Zhang, Yi; James, Roland; Olivier, Michael; Kissebah, Ahmed H.; Network, Reproductive Medicine; Alvero, Ruben; Barnhart, Huiman X.; Baker, Valerie L.; Barnhart, Kurt T.; Bates, G. Wright; Brzyski, Robert G.; Carr, Bruce R.; Carson, Sandra Ann; Casson, Peter R.; Cataldo, Nicholas A.; Christman, Gregory M.; Coutifaris, Christos; Diamond, Michael P.; Eisenberg, Esther; Gosman, Gabriella G.; Giudice, Linda C.; Haisenleder, Daniel J.; Huang, Hao; Krawetz, Stephen A.; Lucidi, Scott; McGovern, Peter G.; Myers, Evan R.; Nestler, John E.; Ohl, Dana A.; Santoro, Nanette; Schlaff, William D.; Snyder, Peter J.; Steinkampf, Michael P.; Trussell, J.C.; Usadi, Rebecca; Yan, Qingshang; Zhang, Heping; Stener‐Victorin, Elisabet; Legro, Richard S.; Dunaif, Andrea

doi:10.1038/ncomms8502

articleNature CommunicationsAug 18, 2015GOLD OA

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

MGM. Geoffrey Hayes MUMargrit Urbanek DADavid A. Ehrmann LLLoren L. Armstrong JYJi Young Lee

Northwestern University · University of Chicago · +41 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Polycystic ovary syndrome (PCOS) is a common, highly heritable complex disorder of unknown aetiology characterized by hyperandrogenism, chronic anovulation and defects in glucose homeostasis. Increased luteinizing hormone relative to follicle-stimulating hormone secretion, insulin resistance and developmental exposure to androgens are hypothesized to play a causal role in PCOS. Here we map common genetic susceptibility loci in European ancestry women for the National Institutes of Health PCOS phenotype, which confers the highest risk for metabolic morbidities, as well as reproductive hormone levels. Three loci reach genome-wide significance in the case-control meta-analysis, two novel loci mapping to chr…

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Topics & keywords

Topics

Keywords

Polycystic ovary
Genome-wide association study
Biology
Secretion
Genetics
Gonadotropin
Genome
Endocrinology

UN Sustainable Development Goals

Good health and well-being

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