High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

Macrophages exhibit phenotypic diversity permitting wide-ranging roles in maintaining physiologic homeostasis. Hyaluronic acid, a major glycosaminoglycan of the extracellular matrix, has been shown to have differential signaling based on its molecular weight. With this in mind, the main objective of this study was to elucidate the role of hyaluronic acid molecular weight on macrophage activation and reprogramming. Changes in macrophage activation were assessed by activation state selective marker measurement, specifically quantitative real time polymerase chain reaction, and cytokine enzyme-linked immunoassays, after macrophage treatment with differing molecular weights of hyaluronic acid under four…

• CC
  Chicago Community Trust
• NI
  National Institute of General Medical Sciences

  Award: R01 GM092850
• NC
  National Center for Advancing Translational Sciences

  Award: UL1 TR000050