Calcium and ROS: A mutual interplay
Deutsches Herzzentrum München · German Centre for Cardiovascular Research · +2 more institutions
Abstract
Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca(2+) signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules…
Citation impact
- FWCI
- 53.18
- Percentile
- 100%
- References
- 190
Authors
4- AGAgnes GörlachCorresponding
Deutsches Herzzentrum München, German Centre for Cardiovascular Research
- KBKatharina Bertram
Deutsches Herzzentrum München
- SHSoňa Hudecová
Slovak Academy of Sciences
- OKOľga KrižanováCorresponding
Slovak Academy of Sciences, Institute of Virology of the Slovak Academy of Sciences
Topics & keywords
- Calcium
- Biology
- Cell biology
- Medicine
- Internal medicine