Physical Principles of Nanoparticle Cellular Endocytosis

This review article focuses on the physiochemical mechanisms underlying nanoparticle uptake into cells. When nanoparticles are in close vicinity to a cell, the interactions between the nanoparticles and the cell membrane generate forces from different origins. This leads to the membrane wrapping of the nanoparticles followed by cellular uptake. This article discusses how the kinetics, energetics, and forces are related to these interactions and dependent on the size, shape, and stiffness of nanoparticles, the biomechanical properties of the cell membrane, as well as the local environment of the cells. The discussed fundamental principles of the physiochemical causes for nanoparticle-cell interaction may guide…

• NS
  National Science Foundation
• PS
  Pennsylvania State University
• NI
  National Institutes of Health
• NH
  National Heart, Lung, and Blood Institute

  Awards: R21 HL122902, HHSN268201000043C
• NE
  National Eye Institute

  Award: PN2EY018244
• DO
  Division of Chemical, Bioengineering, Environmental, and Transport Systems

  Awards: CBET-1067523, CBET-1344097
• DO
  Division of Civil, Mechanical and Manufacturing Innovation

  Awards: CMMI-0754463, CMMI-0644599, CMMI-1028530