Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin-Induced Acute Lung Injury in Mice

We previously found that human mesenchymal stem cells (MSC) or its conditioned medium restored lung protein permeability and reduced alveolar inflammation following Escherichia coli endotoxin-induced acute lung injury (ALI) in an ex vivo perfused human lung in part through the secretion of soluble factors such as keratinocyte growth factor (KGF). Recently, MSC were found to release microvesicles (MVs) that were biologically active because of the presence of mRNA or miRNA with reparative properties. MVs are circular fragments of membrane released from the endosomal compartment as exosomes or shed from the surface membranes. These studies were designed to determine if MVs released by human bone marrow derived…

• NI
  National Institutes of Health

  Awards: HL-093026, Grant # P40RR017447, P40RR017447, HL-51854
• UO
  University of California, San Francisco
• NH
  National Heart, Lung, and Blood Institute

  Awards: 093026, HL-51854, HL-093026, 113022, HL-113022
• NC
  National Center for Research Resources

  Award: P40RR017447