Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis

Boonstra, Kirsten; Weersma, Rinse K.; Erpecum, Karel J. van; Rauws, Erik A.; Spanier, B.W.M.; Poen, Alexander C.; Nieuwkerk, Karin M. van; Drenth, Joost P.H.; Witteman, Ben; Tuynman, Hans A.R.E.; Naber, A.H.J.; Kingma, Paul J.; Buuren, Henk R. van; Hoek, Bart van; Vleggaar, Frank P.; Geloven, Nan van; Beuers, Ulrich; Ponsioen, Cyriel Y.; Group, on behalf of the EpiPSCPBC Study

doi:10.1002/hep.26565

articleHepatologyJun 14, 2013BRONZE OA

Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis

KBKirsten Boonstra RKRinse K. Weersma KJKarel J. van Erpecum EAErik A. Rauws BSB.W.M. Spanier

Academic Medical Center · University of Groningen · +12 more institutions

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Abstract

Extensive population-based studies are much needed to accurately establish epidemiology and disease course in patients with primary sclerosing cholangitis (PSC). We aimed to obtain population-based prevalence and incidence figures, insight in disease course with regard to survival, liver transplantation (LT), and occurrence of malignancies, as well as risk factors thereof. Four independent hospital databases were searched in 44 hospitals in a large geographically defined area of the Netherlands, comprising 50% of the population. In addition, all PSC patients in the three Dutch liver transplant centers and all inflammatory bowel disease (IBD) patients in the adherence area of a large district hospital were…

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Topics & keywords

Topics

Keywords

Primary sclerosing cholangitis
Medicine
Epidemiology
Malignancy
Internal medicine
Population
Gastroenterology
Disease

UN Sustainable Development Goals

Good health and well-being

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