Brain-Derived Neurotrophic Factor val 66 met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
United States Department of Health and Human Services · National Institutes of Health · +2 more institutions
Abstract
BDNF plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. A frequent single nucleotide polymorphism in the targeting region of the human BDNF gene (val66met) has been associated with abnormal intracellular trafficking and regulated secretion of BDNF in cultured hippocampal neurons transfected with the met allele. In addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of BDNF alleles on hippocampal processing of memory has not been demonstrated. We studied the relationship of the BDNF val66met genotype and hippocampal activity during episodic…
Citation impact
- FWCI
- 11.96
- Percentile
- 100%
- References
- 24
Authors
7- ARAhmad R. HaririCorresponding
United States Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, National Institute of Mental Health
- TETerry E. Goldberg
United States Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health
- VSVenkata S. Mattay
United States Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health
- BKBhaskar Kolachana
United States Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health
- JHJoseph H. Callicott
United States Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health
Topics & keywords
- Hippocampal formation
- Episodic memory
- Hippocampus
- Neuroscience
- Neurotrophic factors
- Functional magnetic resonance imaging
- Brain-derived neurotrophic factor
- Psychology