reviewMini-Reviews in Medicinal ChemistryJan 1, 2004Closed access

The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

DGD. Gambinob

Universidade Federal de Minas Gerais

PubMed
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Abstract

The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed. Keywords: Semicarbazones, thiosemicarbazones, biological activity, pharmacological applications, bioactive metal complexes, mechanisms of action

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765
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Authors

1
  • DG
    D. GambinobCorresponding

    Universidade Federal de Minas Gerais

Topics & keywords

Topics
Keywords
  • Antifungal
  • Semicarbazone
  • Chemistry
  • Combinatorial chemistry
  • Metal
  • Stereochemistry
  • Organic chemistry
  • Microbiology
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