Complement System Part I – Molecular Mechanisms of Activation and Regulation
Inserm · Université Paris Cité · +7 more institutions
Abstract
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger signals. The subsequent cascade of enzymatic reactions is tightly regulated to assure that complement is activated only at specific locations requiring defense against pathogens, thus avoiding host tissue damage. Here, we discuss the recent advances describing the molecular and structural basis of activation and regulation of the complement pathways and their implication on physiology and pathology. This article will review the mechanisms of activation of…
Citation impact
- FWCI
- 40.69
- Percentile
- 100%
- References
- 365
Authors
4- NSNicolas S. MerleCorresponding
Inserm, Université Paris Cité, Sorbonne Université, Sorbonne Paris Cité, Centre de Recherche des Cordeliers
- SCS. Church
Inserm, Université Paris Cité, Sorbonne Université, Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Laboratoire d’immunologie intégrative du cancer
- VFVéronique Frémeaux‐Bacchi
Inserm, Université Paris Cité, Sorbonne Université, Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Assistance Publique – Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Hôpital Européen
- LTLubka T. Roumenina
Inserm, Université Paris Cité, Sorbonne Université, Sorbonne Paris Cité, Centre de Recherche des Cordeliers
Topics & keywords
- Complement system
- Anaphylatoxin
- Complement membrane attack complex
- Innate immune system
- Complement (music)
- Alternative complement pathway
- Function (biology)
- Complement receptor
- Good health and well-being