Animal models of schizophrenia

Developing reliable, predictive animal models for complex psychiatric disorders, such as schizophrenia, is essential to increase our understanding of the neurobiological basis of the disorder and for the development of novel drugs with improved therapeutic efficacy. All available animal models of schizophrenia fit into four different induction categories: developmental, drug-induced, lesion or genetic manipulation, and the best characterized examples of each type are reviewed herein. Most rodent models have behavioural phenotype changes that resemble 'positive-like' symptoms of schizophrenia, probably reflecting altered mesolimbic dopamine function, but fewer models also show altered social interaction, and…

• EL
  Eli Lilly and Company
• G
  GlaxoSmithKline
• FH
  F. Hoffmann-La Roche
• S
  Servier
• MR
  Medical Research Council
• BA
  Biotechnology and Biological Sciences Research Council
• ID
  Institut de Recherches Servier