NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy

Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and inhibitory receptors that serve to regulate the function and activity of the cells. In the context of targeting cells, NK cells can be "specifically activated" through certain Fc receptors that are expressed on their cell surface. NK cells can express FcγRIIIA and/or FcγRIIC, which can bind to the Fc portion of immunoglobulins, transmitting activating signals within NK cells. Once activated through Fc receptors by antibodies bound to target cells, NK cells are able to lyse target cells without priming, and secrete cytokines like…

• RS
  Radiological Society of North America
• UO
  University of Wisconsin-Madison
• NI
  National Institutes of Health

  Awards: CA032685, CA87025, CA166105, CA14520
• IF
  Institute for Clinical and Translational Research, University of Wisconsin, Madison
• SU
  Stand Up To Cancer

  Award: SU2C-AACR-DT1113
• HH
  Hyundai Hope On Wheels

  Award: 1TL1RR025013-01