Correlated gene expression supports synchronous activity in brain networks
University of Geneva · Stanford University · +31 more institutions
Abstract
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated…
Citation impact
- FWCI
- 32.96
- Percentile
- 100%
- References
- 52
Authors
129- JRJonas RichiardiCorresponding
University of Geneva, Stanford University
- AAAndré Altmann
Stanford University
- AMAnna-Clare Milazzo
VA Palo Alto Health Care System, Stanford University
- CCCatie Chang
National Institutes of Health, National Institute of Neurological Disorders and Stroke
- MMM. Mallar Chakravarty
Douglas Mental Health University Institute, McGill University
Topics & keywords
- Functional connectivity
- Resting state fMRI
- Neuroscience
- Biology
- Gene
- Functional magnetic resonance imaging
- Gene expression
- Computational biology
Funding
- WWellcome
- CDCalifornia Department of Fish and GameAwards: FOR 1617, SM 80/7-2, SFB 940/1, SM 80/7-1
- NINational Institute for Health and Care Research
- BFBundesministerium für Bildung und ForschungAwards: eMED SysAlc01ZX1311A, 01GS08152, 01EV0711
- FPFondation pour la Recherche Médicale
- MIMission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives
- NINational Institutes of HealthAwards: RO1NS073498, RO1 MH085772-01A1, U54 EB020403
- MRMedical Research Council