Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
National Hospital for Neurology and Neurosurgery · University College London · +1 more institution
Abstract
Strong synchronization of neuronal activity occurs in the 8-35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potential (LFP) activity. To test whether such synchronization may contribute to bradykinesia and rigidity, we sought correlations between the suppression of synchronization at 8-35 Hz in STN and the reduction in Parkinsonism with levodopa. LFPs were recorded on and off medication from STN deep-brain stimulation electrodes in nine PD patients. LFP power was calculated over the frequencies of the most prominent spectral peak within the 8-35 Hz frequency band on each of 17 sides (off medication), and over the frequencies of any…
Citation impact
- FWCI
- 14.60
- Percentile
- 100%
- References
- 22
Authors
4Topics & keywords
- Subthalamic nucleus
- Levodopa
- Parkinsonism
- Local field potential
- Deep brain stimulation
- Parkinson's disease
- Psychology
- Rating scale
- Good health and well-being