Understanding NMR spectroscopy

Detailed notes accompanying a graduate course given in 2002 for the Department of Chemistry, University of California, Irvine. This course is aimed at those who are already familiar with using NMR on a day-to-day basis, but who wish to deepen their understanding of how NMR experiments work and the theory behind them. It will be assumed that you are familiar with the concepts of chemical shifts and couplings, and are used to interpreting proton and 13C spectra. It will also be assumed that you have at least come across simple two-dimensional spectra such as COSY and HMQC, and perhaps may have used such spectra in the course of your work. Similarly, some familiarity with the nuclear Overhauser effect (NOE) will…