Complement System Part II: Role in Immunity
Centre de Recherche des Cordeliers · Sorbonne Paris Cité · +7 more institutions
Abstract
The complement system has been considered for a long time as a simple lytic system, aimed to kill bacteria infecting the host organism. Nowadays this vision has changed and it is well accepted that complement is a complex innate immune surveillance system, playing a key role in host homeostasis, inflammation and in the defense against pathogens. This review discusses recent advances in the understanding of the role of complement in physiology and pathology. It starts with a description of complement contribution to the normal physiology (homeostasis) of a healthy organism, including the silent clearance of apoptotic cells and maintenance of cell survival. In pathology, complement can be a friend or a foe. It…
Citation impact
- FWCI
- 29.30
- Percentile
- 100%
- References
- 300
Authors
5- NSNicolas S. Merle
Centre de Recherche des Cordeliers, Sorbonne Paris Cité, Inserm, Université Paris Cité, Sorbonne Université
- RNRémi Noé
Université Paris Cité, École Pratique des Hautes Études, Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm
- LHLise Halbwachs‐Mecarelli
Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Sorbonne Université, Inserm, Université Paris Cité
- VFVéronique Frémeaux‐Bacchi
Hôpital Européen Georges-Pompidou, Inserm, Sorbonne Paris Cité, Assistance Publique – Hôpitaux de Paris, Sorbonne Université, Université Paris Cité, Hôpital Européen, Centre de Recherche des Cordeliers
- LTLubka T. RoumeninaCorresponding
Sorbonne Paris Cité, Sorbonne Université, Université Paris Cité, Inserm, Centre de Recherche des Cordeliers
Topics & keywords
- Complement system
- Anaphylatoxin
- Immunology
- Complement membrane attack complex
- Immune system
- Complement receptor
- Biology
- Acquired immune system
- Good health and well-being