A Common Allele on Chromosome 9 Associated with Coronary Heart Disease
Lawrence Berkeley National Laboratory · University of Ottawa · +9 more institutions
Abstract
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD.
Citation impact
- FWCI
- 99.09
- Percentile
- 100%
- References
- 15
Authors
13- RMRuth McPhersonCorresponding
Lawrence Berkeley National Laboratory, University of Ottawa, Joint Genome Institute, Mountain View College, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- APAlexander PertsemlidisCorresponding
Lawrence Berkeley National Laboratory, University of Ottawa, Joint Genome Institute, Mountain View College, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- NKNihan Kavaslar
Lawrence Berkeley National Laboratory, University of Ottawa, Joint Genome Institute, Mountain View College, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- AFAlexandre F.R. Stewart
Lawrence Berkeley National Laboratory, University of Ottawa, Joint Genome Institute, Mountain View College, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- RRRobert Roberts
Lawrence Berkeley National Laboratory, University of Ottawa, Joint Genome Institute, Mountain View College, Southwestern Medical Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Allele
- CDKN2A
- Genetics
- Chromosome
- CDKN2B
- Coronary heart disease
- Internal medicine
- Biology
- Good health and well-being