Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
Universität Ulm · Institute for Neurodegenerative Disorders · +1 more institution
Indexed incrossrefpubmed
Abstract
Objective
To see whether the distribution patterns of phosphorylated 43kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropathological stages.
Methods
pTDP-43 immunohistochemistry was performed on 70 μm sections from ALS autopsy cases (N = 76) classified by clinical phenotype and genetic background.
Citation impact
1,061
total citations
- FWCI
- 40.28
- Percentile
- 100%
- References
- 90
Citations per year
Authors
20- JBJohannes Brettschneider
Universität Ulm, Institute for Neurodegenerative Disorders, University of Pennsylvania
- KDKelly Del Tredici
Universität Ulm
- JBJon B. Toledo
Institute for Neurodegenerative Disorders, University of Pennsylvania
- JRJohn Robinson
Institute for Neurodegenerative Disorders, University of Pennsylvania
- DJDavid J. Irwin
Institute for Neurodegenerative Disorders, University of Pennsylvania
Topics & keywords
Topics
Keywords
- Reticular formation
- Pathology
- Brainstem
- Anatomy
- Biology
- Neuroscience
- Central nervous system
- Medicine
UN Sustainable Development Goals
- Good health and well-being
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