The promise and peril of chemical probes

Arrowsmith, C.H.; Audia, James E.; Austin, Christopher P.; Baell, Jonathan B.; Bennett, Jonathan P.; Blagg, Julian; Bountra, C.; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E.; Buser‐Doepner, Carolyn; Campbell, Robert M; Carter, Adrian J.; Cohen, Philip; Copeland, Robert A.; Cravatt, Ben; Dahlin, Jayme L.; Dhanak, Dashyant; Edwards, A.M.; Frederiksen, Mathias; Frye, Stephen V.; Gray, Nathanael S.; Grimshaw, Charles E.; Hepworth, David; Howe, Trevor; Huber, K.; Jin, Jian; Knapp, Stefan; Kotz, Joanne; Kruger, Ryan G.; Lowe, Derek; Mader, Mary M.; Marsden, Brian D.; Mueller‐Fahrnow, Anke; Müller, Susanne; O’Hagan, Rónán C.; Overington, John P.; Owen, Dafydd R.; Rosenberg, Saul H.; Ross, Ruth A.; Roth, Bryan L.; Schapira, Matthieu; Schreiber, Stuart L.; Shoichet, Brian K.; Sundström, M.; Superti-Furga, Giulio; Taunton, Jack; Toledo‐Sherman, Leticia; Walpole, Chris; Walters, Michael A.; Willson, Timothy M.; Workman, Paul; Young, Robert N.; Zuercher, William J.

doi:10.1038/nchembio.1867

articleNature Chemical BiologyJul 21, 2015HYBRID OA

The promise and peril of chemical probes

CAC.H. Arrowsmith JEJames E. Audia CPChristopher P. Austin JBJonathan B. Baell JPJonathan P. Bennett

Princess Margaret Cancer Centre · Structural Genomics Consortium · +43 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.

Citation impact

847

total citations

FWCI: 54.74
Percentile: 100%
References: 41

Citations per year

Authors

CA
C.H. ArrowsmithCorresponding
Princess Margaret Cancer Centre, Structural Genomics Consortium
JE
James E. Audia
Constellation Pharmaceuticals (United States)
CP
Christopher P. Austin
National Institutes of Health, National Center for Advancing Translational Sciences
JB
Jonathan B. Baell
Monash University
JP
Jonathan P. Bennett
Merck & Co., Inc., Rahway, NJ, USA (United States)

Topics & keywords

Topics

Click Chemistry and Applications98%
Chemical Synthesis and Analysis98%
Computational Drug Discovery Methods97%

Keywords

Quality (philosophy)
Computer science
Data science
Resource (disambiguation)
Risk analysis (engineering)
Business
Epistemology

UN Sustainable Development Goals

No poverty

No related works found for this paper.

Funding

EL
Eli Lilly and Company
P
Pfizer
G
GlaxoSmithKline
HU
Harvard University
UO
University of Dundee
CP
Constellation Pharmaceuticals
CR
Cancer Research UK
UO
University of Oxford
MU
Monash University
ÖA
Österreichischen Akademie der Wissenschaften
UO
University of Toronto
NI
National Institutes of Health
UO
University of North Carolina at Chapel Hill
NI
Novartis Institutes for BioMedical Research
MR
Medical Research Council
Award: MR/K000985/1
JR
Janssen Research and Development
NC
National Center for Advancing Translational Sciences
UE
UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill