Synchronization and desynchronization in epilepsy: controversies and hypotheses
Czech Academy of Sciences · Charles University · +6 more institutions
Abstract
Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a hypersynchronous state. Recent evidence showed that epileptiform phenomena, particularly seizures, result from complex interactions between neuronal networks characterized by heterogeneity of neuronal firing and dynamical evolution of synchronization. Desynchronization is often observed preceding seizures or during their early stages; in contrast, high levels of synchronization observed towards the end of seizures may facilitate termination. In this review we discuss cellular and network mechanisms responsible for such complex changes in synchronization. Recent…
Citation impact
- FWCI
- 10.56
- Percentile
- 100%
- References
- 92
Authors
6- PJPřemysl JiruškaCorresponding
Czech Academy of Sciences, Charles University, University of Birmingham
- MDMarco de Curtis
Fondazione IRCCS Istituto Neurologico Carlo Besta
- JGJohn G. R. Jefferys
University of Birmingham
- CACatherine A. Schevon
Columbia University
- SJSteven J. Schiff
Pennsylvania State University
Topics & keywords
- Neuroscience
- Epilepsy
- Synchronization (alternating current)
- Premovement neuronal activity
- Inhibitory postsynaptic potential
- Excitatory postsynaptic potential
- Psychology
- Computer science