The WHO Classification of Tumors of the Nervous System
Heinrich Heine University Düsseldorf · Children's Hospital of Philadelphia · +5 more institutions
Abstract
The new World Health Organization (WHO) classification of nervous system tumors, published in 2000, emerged from a 1999 international consensus conference of neuropathologists. New entities include chordoid glioma of the third ventricle, cerebellar liponeurocytoma, atypical teratoid/rhabdoid tumor, and perineurioma. Several histological variants were added, including tanycytic ependymoma, large cell medulloblastoma, and rhabdoid meningioma. The WHO grading scheme was updated and, for meningiomas, extensively revised. In recognition of the emerging role of molecular diagnostic approaches to tumor classification, genetic profiles have been emphasized, as in the distinct subtypes of glioblastoma and the already…
Citation impact
- FWCI
- 29.45
- Percentile
- 100%
- References
- 83
Authors
7- PKPaul KleihuesCorresponding
Heinrich Heine University Düsseldorf, Children's Hospital of Philadelphia, Johns Hopkins Hospital, WinnMed, Massachusetts General Hospital, Mayo Clinic, Centre International de Recherche sur le Cancer
- DNDavid N. Louis
WinnMed, Johns Hopkins Hospital, Children's Hospital of Philadelphia, Centre International de Recherche sur le Cancer, Heinrich Heine University Düsseldorf, Mayo Clinic, Massachusetts General Hospital
- BWBernd W. Scheithauer
Children's Hospital of Philadelphia, Mayo Clinic, Johns Hopkins Hospital, WinnMed, Massachusetts General Hospital, Centre International de Recherche sur le Cancer, Heinrich Heine University Düsseldorf
- LBLucy B. Rorke
Massachusetts General Hospital, Heinrich Heine University Düsseldorf, Centre International de Recherche sur le Cancer, Mayo Clinic, WinnMed, Johns Hopkins Hospital, Children's Hospital of Philadelphia
- GRGuido Reifenberger
Massachusetts General Hospital, WinnMed, Children's Hospital of Philadelphia, Johns Hopkins Hospital, Mayo Clinic, Heinrich Heine University Düsseldorf, Centre International de Recherche sur le Cancer
Topics & keywords
- Oligodendroglioma
- Pathology
- Grading (engineering)
- Medulloblastoma
- Ependymoma
- Classification scheme
- Meningioma
- Medicine
- Good health and well-being