Widespread seasonal gene expression reveals annual differences in human immunity and physiology

Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of…

• NI
  National Institute for Health and Care Research
• MR
  Medical Research Council

  Award: MC_EX_MR/M01424X/1
• NC
  NIHR Cambridge Biomedical Research Centre