Exosomes with Immune Modulatory Features Are Present in Human Breast Milk

Breast milk is a complex liquid with immune-competent cells and soluble proteins that provide immunity to the infant and affect the maturation of the infant's immune system. Exosomes are nanovesicles (30-100 nm) with an endosome-derived limiting membrane secreted by a diverse range of cell types. Because exosomes carry immunorelevant structures, they are suggested to participate in directing the immune response. We hypothesized that human breast milk contain exosomes, which may be important for the development of the infant's immune system. We isolated vesicles from the human colostrum and mature breast milk by ultracentrifugations and/or immuno-isolation on paramagnetic beads. We found that the vesicles…

• ÅW
  Åke Wiberg Stiftelse
• ES
  European Science Foundation
• KI
  Karolinska Institutet
• V
  Vetenskapsrådet
• MB
  Magnus Bergvalls Stiftelse
• AO
  Astma- och Allergiförbundet