reviewBritish Journal of PharmacologyOct 21, 2011BRONZE OA

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

MRMegan RothAOAmanda ObaidatBHBruno Hagenbuch

University of Kansas Medical Center · The University of Kansas Cancer Center

PubMed
Indexed incrossrefpubmed

Abstract

The human organic anion and cation transporters are classified within two SLC superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting polypeptides (OATPs), while the organic anion transporters (OATs) and the organic cation transporters (OCTs) are classified in the SLC22A superfamily. Individual members of each superfamily are expressed in essentially every epithelium throughout the body, where they play a significant role in drug absorption, distribution and elimination. Substrates of OATPs are mainly large hydrophobic organic anions, while OATs transport smaller and more hydrophilic organic anions and OCTs transport organic cations. In addition to endogenous substrates, such…

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750
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Organic cation transport proteins
  • Transporter
  • Solute carrier family
  • Organic anion transporter 1
  • Biochemistry
  • Organic anion
  • Organic anion-transporting polypeptide
  • ATP-binding cassette transporter
UN Sustainable Development Goals
  • Good health and well-being
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