The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution

It is a widespread notion that the proportion of glial to neuronal cells in the brain increases with brain size, to the point that glial cells represent "about 90% of all cells in the human brain." This notion, however, is wrong on both counts: neither does the glia/neuron ratio increase uniformly with brain size, nor do glial cells represent the majority of cells in the human brain. This review examines the origin of interest in the glia/neuron ratio; the original evidence that led to the notion that it increases with brain size; the extent to which this concept can be applied to white matter and whole brains and the recent supporting evidence that the glia/neuron ratio does not increase with brain size, but…

• JS
  James S. McDonnell Foundation
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico
• FC
  Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro