Resolvin E1 Selectively Interacts with Leukotriene B4 Receptor BLT1 and ChemR23 to Regulate Inflammation
Brigham and Women's Hospital · Harvard University
Abstract
Resolvin E1 (RvE1) is a potent anti-inflammatory and proresolving mediator derived from omega-3 eicosapentaenoic acid generated during the resolution phase of inflammation. RvE1 possesses a unique structure and counterregulatory actions that stop human polymorphonuclear leukocyte (PMN) transendothelial migration and PMN infiltration in several murine inflammatory models. To examine the mechanism(s) underlying anti-inflammatory actions on PMNs, we prepared [(3)H]RvE1 and characterized its interactions with human PMN. Results with membrane fractions of human PMN demonstrated specific binding with a K(d) of 48.3 nM. [(3)H]RvE1 specific binding to human PMN was displaced by leukotriene B(4) (LTB(4)) and LTB(4)…
Citation impact
- FWCI
- 20.41
- Percentile
- 100%
- References
- 34
Authors
6- MAMakoto AritaCorresponding
Brigham and Women's Hospital, Harvard University
- TOTaisuke Ohira
Brigham and Women's Hospital, Harvard University
- YSYee‐Ping Sun
Brigham and Women's Hospital, Harvard University
- SESiva Elangovan
Brigham and Women's Hospital, Harvard University
- NCNan Chiang
Brigham and Women's Hospital, Harvard University
Topics & keywords
- Inflammation
- Leukotriene B4
- Receptor
- Chemistry
- Pharmacology
- Medicine
- Immunology
- Biochemistry