The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
University of California, San Francisco · Neurological Surgery · +1 more institution
Abstract
Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, which are fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBMs), harbor highly recurrent TERT promoter mutations of unknown function but specific to two nucleotide positions. We identified the functional consequence of these mutations in GBMs to be recruitment of the multimeric GA-binding protein (GABP) transcription factor specifically to the mutant promoter. Allelic recruitment of GABP is consistently observed across four cancer types, highlighting a shared mechanism underlying TERT reactivation. Tandem…
Citation impact
- FWCI
- 37.36
- Percentile
- 100%
- References
- 44
Authors
17- RJRobert J.A. Bell
University of California, San Francisco, Neurological Surgery
- HTH. Tomas Rube
University of Illinois Urbana-Champaign
- AKAlex Kreig
University of Illinois Urbana-Champaign
- AMAndrew Mancini
University of California, San Francisco, Neurological Surgery
- SDShaun D. Fouse
University of California, San Francisco, Neurological Surgery
Topics & keywords
- Telomerase
- Promoter
- Mutant
- Molecular biology
- Gene
- Transcription factor
- Biology
- Somatic cell
- Good health and well-being