Microglia and neuroinflammation: a pathological perspective.

Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. Their role in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses. Specific reference is made also to their involvement in Alzheimer's disease where microglial cell activation is thought to be critically important in the neurodegenerative process.

• BR
  Brain Research Foundation
• MF
  McKnight Foundation
• EF
  Evelyn F. McKnight Brain Research Foundation
• UO
  University of Florida
• NI
  National Institutes of Health
• NI
  National Institute of Neurological Disorders and Stroke