Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group
Amsterdam Neuroscience · University of California, Irvine · +30 more institutions
Abstract
Alterations in regional subcortical brain volumes have been investigated as part of the efforts of an international consortium, ENIGMA, to identify reliable neural correlates of major depressive disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work by precisely mapping localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subcortical structures: nucleus…
Citation impact
- FWCI
- 41.62
- Percentile
- 100%
- References
- 96
Authors
63- FTfor the ENIGMA-Major Depressive Disorder Working GroupCorresponding
Amsterdam Neuroscience
- LSLianne Schmaal
Amsterdam Neuroscience
- DJDick J. Veltman
University of California, Irvine, Amsterdam Neuroscience
- TGTheo G.M. van Erp
University of California, Irvine, Max Planck Institute of Psychiatry
- PGPhilipp G. Sämann
Max Planck Institute of Psychiatry, University of Regensburg
Topics & keywords
- Psychology
- Major depressive disorder
- Neuroscience
- Psychiatry
- Medicine
- Clinical psychology
- Cognition
- Reduced inequalities