Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord
Harvard University · Massachusetts General Hospital
Abstract
To clarify whether inhibitory transmission in the superficial dorsal horn of the spinal cord is reduced after peripheral nerve injury, we have studied synaptic transmission in lamina II neurons of an isolated adult rat spinal cord slice preparation after complete sciatic nerve transection (SNT), chronic constriction injury (CCI), or spared nerve injury (SNI). Fast excitatory transmission remains intact after all three types of nerve injury. In contrast, primary afferent-evoked IPSCs are substantially reduced in incidence, magnitude, and duration after the two partial nerve injuries, CCI and SNI, but not SNT. Pharmacologically isolated GABA(A) receptor-mediated IPSCs are decreased in the two partial nerve…
Citation impact
- FWCI
- 13.04
- Percentile
- 100%
- References
- 29
Authors
6- KAKimberly A. MooreCorresponding
Harvard University, Massachusetts General Hospital
- TKTatsuro Kohno
Harvard University, Massachusetts General Hospital
- LALaurie A. Karchewski
Harvard University, Massachusetts General Hospital
- JSJoachim Scholz
Massachusetts General Hospital, Harvard University
- HBHiroshi Baba
Harvard University, Massachusetts General Hospital
Topics & keywords
- Glutamate decarboxylase
- Peripheral nerve injury
- Nerve injury
- Spinal cord
- SNi
- Sciatic nerve
- Neurotransmission
- GABAergic
- Good health and well-being