articlePubMedAug 1, 2008GREEN OA

Limit of blank, limit of detection and limit of quantitation.

DADavid ArmbrusterTPTerry Pry

Abbott Fund

PubMed
Indexed inpubmed

Abstract

* Limit of Blank (LoB), Limit of Detection (LoD), and Limit of Quantitation (LoQ) are terms used to describe the smallest concentration of a measurand that can be reliably measured by an analytical procedure. * LoB is the highest apparent analyte concentration expected to be found when replicates of a blank sample containing no analyte are tested. LoB = mean(blank) + 1.645(SD(blank)). * LoD is the lowest analyte concentration likely to be reliably distinguished from the LoB and at which detection is feasible. LoD is determined by utilising both the measured LoB and test replicates of a sample known to contain a low concentration of analyte. * LoD = LoB + 1.645(SD (low concentration sample)). * LoQ is the…

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Topics & keywords

Topics
Keywords
  • Blank
  • Analyte
  • Detection limit
  • Chromatography
  • Limit (mathematics)
  • Analytical Chemistry (journal)
  • Chemistry
  • Sample (material)
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