Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure-Activity Relationships

This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences, and that reduce, refine or replace the use of laboratory animals. The ECVAM workshop on the quantitative structure-activity relationship applicability domain was held at ECVAM on 29 September–1 October 2004, under the chairmanship of Andrew Worth. The workshop was attended by experts from academia, industry, international organisations and regulatory authorities. The aim of…