The who's who of T ‐cell differentiation: Human memory T ‐cell subsets

Following antigen encounter and subsequent resolution of the immune response, a single naïve T cell is able to generate multiple subsets of memory T cells with different phenotypic and functional properties and gene expression profiles. Single-cell technologies, first and foremost flow cytometry, have revealed the complex heterogeneity of the memory T-cell compartment and its organization into subsets. However, a consensus has still to be reached, both at the semantic (nomenclature) and phenotypic level, regarding the identification of these subsets. Here, we review recent developments in the characterization of the heterogeneity of the memory T-cell compartment, and propose a unified classification of both…

• NS
  National Science Foundation
• EC
  European Commission

  Awards: FP7-HEALTH-F3-2009-241745, 241745, 322093
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Award: 131092
• FC
  Fondazione Cariplo
• AI
  Associazione Italiana per la Ricerca sul Cancro
• NI
  National Institutes of Health
• NI
  National Institute of Allergy and Infectious Diseases
• FH
  FP7 Health