Arginase: an emerging key player in the mammalian immune system
Heidelberg University · University Hospital Heidelberg
Abstract
The enzyme arginase metabolizes L-arginine to L-ornithine and urea. Besides its fundamental role in the hepatic urea cycle, arginase is also expressed the immune system of mice and man. While significant interspecies differences exist regarding expression, subcellular localization and regulation of immune cell arginase, associated pathways of immunopathology are comparable between species. Arginase is induced in murine myeloid cells mainly by Th2 cytokines and inflammatory agents and participates in a variety of inflammatory diseases by down-regulation of nitric oxide synthesis, induction of fibrosis and tissue regeneration. In humans, arginase I is constitutively expressed in polymorphonuclear neutrophils and…
Citation impact
- FWCI
- 9.10
- Percentile
- 100%
- References
- 159
Authors
1Topics & keywords
- Arginase
- Immune system
- Biology
- Inflammation
- T cell
- Ornithine
- Immunology
- Cell biology