reviewInternal Medicine JournalFeb 28, 2012BRONZE OA

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta‐analysis of longitudinal studies

The Affiliated Yongchuan Hospital of Chongqing Medical University · Chongqing Medical University · +3 more institutions

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Abstract

This study examined the association of diabetes with the onset of dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) and mild cognitive impairment (MCI) by using a quantitative meta-analysis of longitudinal studies. EMBASE and MEDLINE were searched for articles published up to December 2010. All studies that examined the relationship between diabetes and the onset of dementia or MCI were included. Pooled relative risks were calculated using fixed and random effects models. Nineteen studies met our inclusion criteria for this meta-analysis, and 6184 subjects with diabetes and 38 530 subjects without diabetes were included respectively. All subjects were without dementia or…

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