reviewBioMed Research InternationalJan 1, 2015HYBRID OA

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

RFRinaldo Florencio‐SilvaGRGisela Rodrigues da Silva SassoESEstela Sasso‐CerriMDManuel de Jesus SimõesPSPaulo Sérgio Cerri

Universidade Federal de São Paulo · Universidade Estadual Paulista (Unesp)

PubMed
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Abstract

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone…

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1,950
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Authors

5

Topics & keywords

Topics
Keywords
  • Bone remodeling period
  • Osteocyte
  • Bone resorption
  • Bone remodeling
  • Bone cell
  • Osteoclast
  • Osteoblast
  • Cell biology
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