reviewBioMed Research InternationalJan 1, 2015HYBRID OA

Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies

AZAgnieszka ZimnaMKMaciej Kurpisz

Institute of Human Genetics · Polish Academy of Sciences

PubMed
Indexed incrossrefdoajpubmed

Abstract

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues, and organs. Under extended exposure to reduced oxygen levels, cells are able to survive through the transcriptional activation of a series of genes that participate in angiogenesis, glucose metabolism, and cell proliferation. The oxygen-sensitive transcriptional activator HIF-1 (hypoxia-inducible factor-1) is a key transcriptional mediator of the response to hypoxic conditions. The HIF-1 pathway was found to be a master regulator of angiogenesis. Whether the process is physiological or pathological, HIF-1 seems to participate in vasculature formation by synergistic correlations with other proangiogenic factors such as…

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Topics & keywords

Topics
Keywords
  • Angiogenesis
  • Vasculogenesis
  • Vascular endothelial growth factor
  • Hypoxia-inducible factors
  • Neovascularization
  • Mediator
  • Hypoxia (environmental)
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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