Innate lymphoid cells: A new paradigm in immunology

Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or…

• W
  Wellcome
• AN
  Agence Nationale de la Recherche
• IN
  Institut National de la Santé et de la Recherche Médicale
• IP
  Institut Pasteur
• LC
  Ligue Contre le Cancer
• NI
  National Institutes of Health

  Awards: 1U01AI095542, R01DE021255, R21CA16719
• MR
  Medical Research Council