reviewFrontiers in PharmacologyJul 1, 2014GOLD OA

Glutathione and mitochondria

VRVicent RibasCGCarmen García-RuizJCJosé C. Fernández-Checa

Consejo Superior de Investigaciones Científicas · Institut d'Investigacions Biomèdiques de Barcelona · +3 more institutions

PubMed
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Abstract

Glutathione (GSH) is the main non-protein thiol in cells whose functions are dependent on the redox-active thiol of its cysteine moiety that serves as a cofactor for a number of antioxidant and detoxifying enzymes. While synthesized exclusively in the cytosol from its constituent amino acids, GSH is distributed in different compartments, including mitochondria where its concentration in the matrix equals that of the cytosol. This feature and its negative charge at physiological pH imply the existence of specific carriers to import GSH from the cytosol to the mitochondrial matrix, where it plays a key role in defense against respiration-induced reactive oxygen species and in the detoxification of lipid…

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553
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Glutathione
  • Cytosol
  • Mitochondrion
  • Mitochondrial intermembrane space
  • Intermembrane space
  • Mitochondrial matrix
  • Programmed cell death
  • Biochemistry
UN Sustainable Development Goals
  • Good health and well-being
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