Abstract
Results
MiR-93 was upregulated in HepG2 cells compared with PHHC and inhibition of miR-93 significantly suppressed HepG2 cell proliferation, migration and col-ony formation. The expressions of TGFBR2 and ITGB8 were upregulated when miR-93 was inhibited.
Conclusions
Our results reveal an important contribution for miR-93 in hepatocarcinogenesis and suggest a role for TGFBR2 and ITGB8 dysregulation in this process. Thus,the use of synthetic inhibitor of miR-93 may prove to bea promising approach to liver cancer treatment.
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Authors
6Topics & keywords
Keywords
- Cell growth
- Flow cytometry
- Cell cycle
- Chemistry
- Western blot
- Downregulation and upregulation
- Molecular biology
- Apoptosis
UN Sustainable Development Goals
- Good health and well-being
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