articleMoleculesJun 26, 2015GOLD OA

The Anticancer, Antioxidant and Antimicrobial Properties of the Sesquiterpene β-Caryophyllene from the Essential Oil of Aquilaria crassna

SSSaad Sabbar DahhamYTYasser TabanaMAMuhammad Adnan IqbalMBMohamed B. Khadeer AhamedMOMohammed Oday Ezzat

Universiti Sains Malaysia

PubMed
Indexed incrossrefdoajpubmed

Abstract

The present study reports a bioassay-guided isolation of β-caryophyllene from the essential oil of Aquilaria crassna. The structure of β-caryophyllene was confirmed using FT-IR, NMR and MS. The antimicrobial effect of β-caryophyllene was examined using human pathogenic bacterial and fungal strains. Its anti-oxidant properties were evaluated by DPPH and FRAP scavenging assays. The cytotoxicity of β-caryophyllene was tested against seven human cancer cell lines. The corresponding selectivity index was determined by testing its cytotoxicity on normal cells. The effects of β-caryophyllene were studied on a series of in vitro antitumor-promoting assays using colon cancer cells. Results showed that β-caryophyllene…

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Topics & keywords

Topics
Keywords
  • Caryophyllene
  • Antimicrobial
  • Chemistry
  • Cytotoxicity
  • DPPH
  • Traditional medicine
  • Apoptosis
  • Antioxidant
UN Sustainable Development Goals
  • Good health and well-being
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