MHC studies in nonmodel vertebrates: what have we learned about natural selection in 15 years?
Université Laval · Harvard University
Abstract
Elucidating how natural selection promotes local adaptation in interaction with migration, genetic drift and mutation is a central aim of evolutionary biology. While several conceptual and practical limitations are still restraining our ability to study these processes at the DNA level, genes of the major histocompatibility complex (MHC) offer several assets that make them unique candidates for this purpose. Yet, it is unclear what general conclusions can be drawn after 15 years of empirical research that documented MHC diversity in the wild. The general objective of this review is to complement earlier literature syntheses on this topic by focusing on MHC studies other than humans and mice. This review first…
Citation impact
- FWCI
- 7.82
- Percentile
- 100%
- References
- 94
Authors
2Topics & keywords
- Biology
- Natural selection
- Major histocompatibility complex
- Evolutionary biology
- Balancing selection
- Selection (genetic algorithm)
- Local adaptation
- Population