Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system
University of St Andrews · University of Edinburgh
Abstract
Differential mRNA expression studies implicitly assume that changes in mRNA expression have biological meaning, most likely mediated by corresponding changes in protein levels. Yet studies into mRNA-protein correspondence have shown notoriously poor correlation between mRNA and protein expression levels, creating concern for inferences from only mRNA expression data. However, none of these studies have examined in particular differentially expressed mRNA. Here, we examined this question in an ovarian cancer xenograft model. We measured protein and mRNA expression for twenty-nine genes in four drug-treatment conditions and in untreated controls. We identified mRNAs differentially expressed between drug-treated…
Citation impact
- FWCI
- 14.91
- Percentile
- 100%
- References
- 37
Authors
5Topics & keywords
- Messenger RNA
- Gene expression
- Biology
- P-bodies
- Gene
- Molecular biology
- Protein biosynthesis
- Translation (biology)