The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
University of Cambridge · Bridge University · +9 more institutions
Abstract
The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism. The PPP is important to maintain carbon homoeostasis, to provide precursors for nucleotide and amino acid biosynthesis, to provide reducing molecules for anabolism, and to defeat oxidative stress. The PPP shares reactions with the Entner-Doudoroff pathway and Calvin cycle and divides into an oxidative and non-oxidative branch. The oxidative branch is highly active in most eukaryotes and converts glucose 6-phosphate into carbon dioxide, ribulose 5-phosphate and NADPH. The latter function is critical to maintain redox balance under stress situations, when cells proliferate rapidly, in ageing, and for the 'Warburg effect' of…
Citation impact
- FWCI
- 24.33
- Percentile
- 100%
- References
- 418
Authors
15Topics & keywords
- Pentose phosphate pathway
- Biochemistry
- Oxidative phosphorylation
- Glycolysis
- Metabolism
- Metabolic pathway
- Sugar phosphates
- Ribose
Funding
- WWellcomeAward: RG 093735/Z/10/Z
- UOUniversity of Rochester
- WTWellcome TrustAward: RG 093735/Z/10/Z
- CRCancer Research UKAward: C197/A3514
- UOUniversity of Oxford
- ECEuropean CommissionAwards: 322842, 260809
- DFDeutsche ForschungsgemeinschaftAward: 1527/1-1
- ASAustrian Science FundAwards: S9302-B05, J 3341
- EREuropean Research CouncilAward: 260809