Central role of the brain in stress and adaptation: Links to socioeconomic status, health, and disease

The brain is the key organ of stress reactivity, coping, and recovery processes. Within the brain, a distributed neural circuitry determines what is threatening and thus stressful to the individual. Instrumental brain systems of this circuitry include the hippocampus, amygdala, and areas of the prefrontal cortex. Together, these systems regulate physiological and behavioral stress processes, which can be adaptive in the short-term and maladaptive in the long-term. Importantly, such stress processes arise from bidirectional patterns of communication between the brain and the autonomic, cardiovascular, and immune systems via neural and endocrine mechanisms underpinning cognition, experience, and behavior. In one…

• JD
  John D. and Catherine T. MacArthur Foundation
• NI
  National Institutes of Health

  Awards: MH58911, R01 HL089850, MH41256, HL089850