A common polymorphism in the brain‐derived neurotrophic factor gene ( BDNF ) modulates human cortical plasticity and the response to rTMS
National Hospital for Neurology and Neurosurgery · University College London · +3 more institutions
Abstract
The brain-derived neurotrophic factor gene (BDNF) is one of many genes thought to influence synaptic plasticity in the adult brain and shows a common single nucleotide polymorphism (BDNF Val66Met) in the normal population that is associated with differences in hippocampal volume and episodic memory. It is also thought to influence possible synaptic changes in motor cortex following a simple motor learning task. Here we extend these studies by using new non-invasive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (TDCS) techniques that directly test the excitability and plasticity of neuronal circuits in human motor cortex in subjects at rest. We investigated whether the…
Citation impact
- FWCI
- 25.97
- Percentile
- 100%
- References
- 29
Authors
10- BCBinith CheeranCorresponding
National Hospital for Neurology and Neurosurgery, University College London
- PTPenelope Talelli
National Hospital for Neurology and Neurosurgery, University College London
- FMFrancesco Mori
University of Rome Tor Vergata, Fondazione Santa Lucia, National Hospital for Neurology and Neurosurgery, University College London
- GKGiacomo Koch
University of Rome Tor Vergata, Fondazione Santa Lucia, National Hospital for Neurology and Neurosurgery, University College London
- ASAntonio Suppa
National Hospital for Neurology and Neurosurgery, University College London, Sapienza University of Rome
Topics & keywords
- Neuroscience
- Transcranial magnetic stimulation
- Neurotrophic factors
- Neuroplasticity
- Motor cortex
- Psychology
- Brain-derived neurotrophic factor
- Synaptic plasticity
- Good health and well-being