Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug combination is usually classified as synergistic or antagonistic, depending on the deviation of the observed combination response from the expected effect calculated based on a reference model of non-interaction. The existing reference models were proposed originally for low-throughput drug combination experiments, which make the model assumptions often incompatible with the complex drug interaction patterns across various dose pairs that are typically observed in large-scale dose-response matrix experiments. To address these limitations, we proposed a novel…

• EC
  European Commission

  Awards: 272437, 2014-2020, 634143
• AO
  Academy of Finland

  Awards: 272437, 279163, 292611, 277293, 269862
• S
  Syöpäjärjestöt