reviewMedicinal Research ReviewsMay 1, 2012GREEN OA

Small Molecule Modulators of K eap1‐ N rf2‐ ARE Pathway as Potential Preventive and Therapeutic Agents

SMSadagopan MageshYCYu ChenLHLongqin Hu

Rutgers, The State University of New Jersey · Cancer Institute of Florida · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elements (ARE) pathway represents one of the most important cellular defense mechanisms against oxidative stress and xenobiotic damage. Activation of Nrf2 signaling induces the transcriptional regulation of ARE-dependent expression of various detoxifying and antioxidant defense enzymes and proteins. Keap1-Nrf2-ARE signaling has become an attractive target for the prevention and treatment of oxidative stress-related diseases and conditions including cancer, neurodegenerative, cardiovascular, metabolic, and inflammatory diseases. Over the last few decades, numerous Nrf2 inducers have been developed…

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Authors

3

Topics & keywords

Topics
Keywords
  • Oxidative stress
  • KEAP1
  • Signal transduction
  • Chemistry
  • Small molecule
  • Cancer
  • Cancer research
  • Pharmacology
UN Sustainable Development Goals
  • Good health and well-being
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