reviewPubMedJun 1, 2002Closed access

Tight junctions of the blood-brain barrier: development, composition and regulation.

HWHartwig WolburgALAndrea Lippoldt

University of Tübingen · Max Delbrück Center · +1 more institution

PubMed
Indexed inpubmed

Abstract

1. The blood-brain barrier is essential for the maintenance and regulation of the neural microenvironment. The main characteristic features of blood-brain barrier endothelial cells are an extremely low rate of transcytotic vesicles and a restrictive paracellular diffusion barrier. 2. Endothelial blood-brain barrier tight junctions differ from epithelial tight junctions, not only by distinct morphological and molecular properties, but also by the fact that endothelial tight junctions are more sensitive to microenvironmental than epithelial factors. 3. Many ubiquitous molecular tight junction components have been identified and characterized including claudins, occludin, ZO-1, ZO-2, ZO-3, cingulin and 7H6.…

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1,149
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Authors

2

Topics & keywords

Topics
Keywords
  • Tight junction
  • Adherens junction
  • Occludin
  • Paracellular transport
  • Claudin
  • Septate junctions
  • Cell biology
  • Blood–brain barrier
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