The human transcriptome across tissues and individuals

Melé, Marta; Ferreira, Pedro G.; Reverter, Ferrán; DeLuca, David S.; Monlong, Jean; Sammeth, Michael; Young, Taylor; Goldmann, Jakob M.; Pervouchine, Dmitri D.; Sullivan, Timothy J.; Johnson, Rory; Segrè, Ayellet V.; Djebali, Sarah; Niarchou, Anastasia; Wright, Fred A.; Lappalainen, Tuuli; Calvo, Miquel; Getz, Gad; Dermitzakis, Emmanouil T.; Ardlie, Kristin; Guigó, Roderic

doi:10.1126/science.aaa0355

articleScienceMay 7, 2015GREEN OA

The human transcriptome across tissues and individuals

MMMarta Melé PGPedro G. Ferreira FRFerrán Reverter DSDavid S. DeLuca JMJean Monlong

Centre for Genomic Regulation · Harvard Stem Cell Institute · +16 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Transcriptional regulation and posttranscriptional processing underlie many cellular and organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue Expression (GTEx) project to investigate the patterns of transcriptome variation across individuals and tissues. Tissues exhibit characteristic transcriptional signatures that show stability in postmortem samples. These signatures are dominated by a relatively small number of genes—which is most clearly seen in blood—though few are exclusive to a particular tissue and vary more across tissues than individuals. Genes exhibiting high interindividual expression variation include disease candidates associated with sex, ethnicity, and age. Primary…

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Topics & keywords

Topics

Keywords

Biology
Genetic variation
Transcriptome
Gene
Gene expression
Expression quantitative trait loci
Genetics
Genotype

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