reviewChemical Society ReviewsJan 1, 2015GREEN OA

Ferrocifen type anti cancer drugs

Centre National de la Recherche Scientifique · Chimie ParisTech · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Despite current developments in therapeutics focusing on biotechnologically-oriented species, the unflagging utility of small molecules or peptides in medicine is still producing strong results. In 2014 for example, of the 41 new medicines authorized for sale, 33 belonged to the category of small molecules, while in 2013 they represented 24 of 27, according to the FDA. This can be explained as the result of recent forays into new or long-neglected areas of chemistry. Medicinal organometallic chemistry can provide us with an antimalarial against resistant parasitic strains, as attested by the phase II clinical development of ferroquine, with a new framework for conceptual advances based on three-dimensional…

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