Ferrocifen type anti cancer drugs
Centre National de la Recherche Scientifique · Chimie ParisTech · +5 more institutions
Abstract
Despite current developments in therapeutics focusing on biotechnologically-oriented species, the unflagging utility of small molecules or peptides in medicine is still producing strong results. In 2014 for example, of the 41 new medicines authorized for sale, 33 belonged to the category of small molecules, while in 2013 they represented 24 of 27, according to the FDA. This can be explained as the result of recent forays into new or long-neglected areas of chemistry. Medicinal organometallic chemistry can provide us with an antimalarial against resistant parasitic strains, as attested by the phase II clinical development of ferroquine, with a new framework for conceptual advances based on three-dimensional…
Citation impact
- FWCI
- 26.76
- Percentile
- 100%
- References
- 77
Authors
3- GJGérard JaouenCorresponding
Centre National de la Recherche Scientifique, Chimie ParisTech, Université Paris Sciences et Lettres, Sorbonne Université, Délégation Ile-de-France Villejuif, UPMC Health System, Institut Parisien de Chimie Moléculaire
- AVAnne Vessières
Centre National de la Recherche Scientifique, Sorbonne Université, Délégation Ile-de-France Villejuif, UPMC Health System, Institut Parisien de Chimie Moléculaire
- STSiden Top
Centre National de la Recherche Scientifique, Sorbonne Université, Délégation Ile-de-France Villejuif, UPMC Health System, Institut Parisien de Chimie Moléculaire
Topics & keywords
- Context (archaeology)
- Small molecule
- Chemistry
- Chemical space
- Redox
- Combinatorial chemistry
- Ferrocene
- Computational biology